The aim of the present study was the effect of cycloheptaamylose (Î²â€‘cyclodextrin) on the dissolution of [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid] (Gemfibrozil) inclusion complexes. Molecular inclusion complexes in 1:1ratio were prepared using a kneading method. The dissolution of pure drug, physical mixtures, and cyclodextrin inclusion complexes was carried out. Molecular inclusion complexes of [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid]with cycloheptaamylose showed a considerable increase in the dissolution rate in comparison with the physical mixture and pure drug in ,double distrilled water pH 5.86, 0.1 N HCl, pH 1.24, and phosphate buffer, pH 7.5. Inclusion complexes with a 1:1 M ratio showed the maximum dissolution rate in comparison to other ratios. Fourier transform infrared spectroscopy and differential scanning calorimetry studies indicated no interaction between [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid] and cycloheptaamylose in complexes in solid state. Dissolution enhancement was attributed to the formation of water soluble inclusion complexes with cycloheptaamylose. The dissolution of [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid] can be increase by the use of a drug carrier like cycloheptaamylose.
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