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Current Trends in Science and Technology

an Open Access Publication ISSN: 0976-9730 | 0976-9498

Chemistry

Dissolution behavior of [5-(2, 5-Dimethylphenoxy)-2,2-dimethylpentanoic acid] with β-cyclodextrin inclusion complexes

RUMAL SINGH, MONIKA TRIVEDI QURRATUL AIN
1Jayoti Vidyapeeth Women’s University Jaipur, Rajasthan, India. 2Jayoti Vidyapeeth Women’s University Jaipur, Rajasthan, India. 3Shri Ganpati Institute of Technology N.H -24 Near Jindal Nagar, Ghaziabad U.P., India.
Online First: April 30, 2018
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Abstract

The aim of the present study was the effect of cycloheptaamylose (β‑cyclodextrin) on the dissolution of   [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid] (Gemfibrozil) inclusion complexes.  Molecular   inclusion complexes in 1:1ratio were prepared using a kneading method. The dissolution of pure drug, physical mixtures, and cyclodextrin inclusion complexes was carried out. Molecular inclusion complexes of  [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid]with   cycloheptaamylose showed a considerable increase in the dissolution rate in comparison with the physical mixture and pure drug in ,double distrilled  water pH 5.86, 0.1 N HCl, pH 1.24, and phosphate buffer, pH 7.5. Inclusion complexes with a 1:1 M ratio showed the maximum dissolution rate in comparison to other ratios. Fourier transform infrared spectroscopy and differential scanning calorimetry studies indicated no interaction between [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid] and cycloheptaamylose in complexes in solid state. Dissolution enhancement was attributed to the formation of water soluble inclusion complexes with cycloheptaamylose. The dissolution of  [5-(2, 5-Dimethylphenoxy)-2, 2-dimethylpentanoic acid]  can be increase by the use of a drug  carrier like cycloheptaamylose.

  Submitted
Jul 3, 2018
Published
Apr 30, 2018
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