Formulation and Evaluation of Oleanolic Acid Loaded Transdermal Patches

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Rajesh Kumar, Prashanta Bose,Ajeet Pal Singh, , Prachi Sharma, Amar Pal Singh
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Transdermal drug delivery system constitutes one of the most important routes for new drug delivery system. Transdermal delivery of drugs offers several advantages over conventional delivery methods. Transdermal delivery, that traditionally uses a patch containing drug substance pressed onto the skin, is non-invasive, convenient and painless, and can avoid gastrointestinal toxicity (e.g. peptic ulcer disease) and the hepatic first pass metabolism. Transdermal delivery of drugs through the skin to the systemic circulation provides a convenient route of administration for a variety of clinical indications.

In present study, attempt is made to prepare transdermal patches containing an anti- inflammatory drug such as oleanic acid along with various polymers for controlled release action. In present study, attempt was made to prepare Transdermal patches containing an anti-inflammatory drug such as oleanic acid along with various polymers for controlled release action. The Transdermal patch of oleanic acid was prepared successfully by solvent evaporation method. Transdermal patch of oleanic acid for Transdermal drug delivery was evaluated. Calibration curve was obtained; Transdermal film was prepared, overcome limitations regarding bioavailability of drug was done. Characterization was done by morphological study (SEM Analysis).


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, PRACHI SHARMA, AMAR PAL SINGH, Rajesh Kumar, Prashanta Bose,Ajeet Pal Singh,. Formulation and Evaluation of Oleanolic Acid Loaded Transdermal Patches. International Journal of Current Trends in Science and Technology, [S.l.], v. 8, n. 03, p. 20196-20205, mar. 2018. ISSN 0976-9730. Available at: <>. Date accessed: 14 dec. 2018. doi:
Pharmaceutical Sciences


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